Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies.
|
31564439 |
2019 |
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa.
|
31394756 |
2019 |
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa.
|
31394756 |
2019 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKD was a significant interaction term in the associations of NOTCH1 and Spondin-1 with HF.
|
30557359 |
2018 |
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKD was a significant interaction term in the associations of NOTCH1 and Spondin-1 with HF.
|
30557359 |
2018 |
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
CKD was a significant interaction term in the associations of NOTCH1 and Spondin-1 with HF.
|
30557359 |
2018 |
ST segment elevation myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among heparin-affected proteins in both the discovery study and the validation study were midkine, spondin 1, secreted frizzled-like protein 1, lipoprotein lipase, and follistatin, all previously associated with STEMI.
|
30115630 |
2018 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Alzheimer's Disease
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
The rs2618516 in the spondin 1 gene (SPON1) has been associated with AD risk and brain structure in the elderly.
|
29573041 |
2018 |
Glucose tolerance test
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic determinants of circulating GIP and GLP-1 concentrations.
|
29093273 |
2017 |
Glucagon measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic determinants of circulating GIP and GLP-1 concentrations.
|
29093273 |
2017 |
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
In pooled analysis of both cohorts, higher levels of nine proteins were associated with incident heart failure after adjustment for established risk factors: growth differentiation factor 15 (GDF-15), T-cell immunoglobulin and mucin domain 1 (TIM-1), tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), spondin-1 (SPON1), matrix metalloproteinase-12 (MMP-12), follistatin (FS), urokinase-type plasminogen activator surface receptor (U-PAR), osteoprotegerin (OPG), and suppression of tumorigenicity 2 (ST2).
|
28967680 |
2018 |
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
In pooled analysis of both cohorts, higher levels of nine proteins were associated with incident heart failure after adjustment for established risk factors: growth differentiation factor 15 (GDF-15), T-cell immunoglobulin and mucin domain 1 (TIM-1), tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), spondin-1 (SPON1), matrix metalloproteinase-12 (MMP-12), follistatin (FS), urokinase-type plasminogen activator surface receptor (U-PAR), osteoprotegerin (OPG), and suppression of tumorigenicity 2 (ST2).
|
28967680 |
2018 |
Vitamin D3 measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
|
28757204 |
2017 |
Vitamin D measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
|
28757204 |
2017 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using a shotgun proteomic approach, high-mobility-group protein B1 and spondin-1 were significantly increased in T2D aorta compared to control aorta, suggesting vascular inflammation and smooth muscle proliferation, respectively.
|
27796656 |
2017 |
Cerebral atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetics dataset yielded two subtypes of AD characterized mainly by the presence/absence of the apolipoprotein E (APOE) ε4 genotype, but also involving differential presence of risk alleles of CD2AP, SPON1 and LOC39095 SNPs that were associated with differences in the respective patterns of brain atrophy, especially in the precuneus.
|
26923371 |
2017 |
Brain atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetics dataset yielded two subtypes of AD characterized mainly by the presence/absence of the apolipoprotein E (APOE) ε4 genotype, but also involving differential presence of risk alleles of CD2AP, SPON1 and LOC39095 SNPs that were associated with differences in the respective patterns of brain atrophy, especially in the precuneus.
|
26923371 |
2017 |
Cartilaginous exostosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Then we demonstrated that SPON1 was significantly up-regulated in 72 osteosarcoma specimens compared with benign osteochondroma samples and elevated SPON1 was positively correlated with MMP9 expression.
|
26032498 |
2015 |
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study provides evidence of the contributions of SPON1 and the Fak and Src signaling to the progression of osteosarcoma and suggests that this axis may represent a potential therapeutic target for osteosarcoma.
|
26032498 |
2015 |
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Meanwhile, suppression of SPON1 in KHOS cells resulted in decreased pulmonary metastasis in vivo.
|
26032498 |
2015 |
Metastatic osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of SPON1 expression in two metastatic osteosarcoma cell lines, HKOS and KRIB, dramatically suppressed cell migration and invasion.
|
26032498 |
2015 |